About Gap junction alpha-9 protein
Gap junction alpha-9 protein (GJA9) is a protein
from Homo sapiens identified by UniProt accession
P57773, 515 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Gap junction alpha-9 protein |
|---|
| UniProt accession | P57773 |
|---|
| Gene | GJA9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 515 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (25)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.25
- mathematical ability · score 0.24
- Kunitz-type protease inhibitor 1 measurement · score 0.21
- blood protein measurement · score 0.21
- triglyceride measurement · score 0.17
- sex hormone-binding globulin measurement · score 0.17
- age at menopause · score 0.16
- gut microbiome measurement · score 0.16
- diffuse plaque measurement · score 0.16
- lung adenocarcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P57773-F1 | alphafold | PREDICTED | 61.29 | — |
Amino-acid sequence (515 residues)
MGDWNLLGDT LEEVHIHSTM IGKIWLTILF IFRMLVLGVA AEDVWNDEQS GFICNTEQPG CRNVCYDQAF PISLIRYWVL QVIFVSSPSL VYMGHALYRL RVLEEERQRM KAQLRVELEE VEFEMPRDRR RLEQELCQLE KRKLNKAPLR GTLLCTYVIH IFTRSVVEVG FMIGQYLLYG FHLEPLFKCH GHPCPNIIDC FVSRPTEKTI FLLFMQSIAT ISLFLNILEI FHLGFKKIKR GLWGKYKLKK EHNEFHANKA KQNVAKYQST SANSLKRLPS APDYNLLVEK QTHTAVYPSL NSSSVFQPNP DNHSVNDEKC ILDEQETVLS NEISTLSTSC SHFQHISSNN NKDTHKIFGK ELNGNQLMEK RETEGKDSKR NYYSRGHRSI PGVAIDGENN MRQSPQTVFS LPANCDWKPR WLRATWGSST EHENRGSPPK GNLKGQFRKG TVRTLPPSQG DSQSLDIPNT ADSLGGLSFE PGLVRTCNNP VCPPNHVVSL TNNLIGRRVP TDLQI
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