F-box/WD repeat-containing protein 4 (FBXW4)

About F-box/WD repeat-containing protein 4

F-box/WD repeat-containing protein 4 (FBXW4) is a protein from Homo sapiens identified by UniProt accession P57775, 412 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	F-box/WD repeat-containing protein 4
UniProt accession	P57775
Gene	FBXW4
Organism	Homo sapiens
Length	412 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

Split hand-split foot malformation · score 0.42
split hand-foot malformation 3 · score 0.42
neurodegenerative disease · score 0.40
lung adenocarcinoma · score 0.25
head and neck squamous cell carcinoma · score 0.25
esophageal cancer · score 0.25
gastric adenocarcinoma · score 0.25
breast adenocarcinoma · score 0.25
body height · score 0.22
hepatocellular carcinoma · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P57775-F1	alphafold	PREDICTED	90.53	—

Amino-acid sequence (412 residues)

MAAAAGEEEE EEEAARESAA RPAAGPALWR LPEELLLLIC SYLDMRALGR LAQVCRWLRR FTSCDLLWRR IARASLNSGF TRLGTDLMTS VPVKERVKVS QNWRLGRCRE GILLKWRCSQ MPWMQLEDDS LYISQANFIL AYQFRPDGAS LNRRPLGVFA GHDEDVCHFV LANSHIVSAG GDGKIGIHKI HSTFTVKYSA HEQEVNCVDC KGGIIVSGSR DRTAKVWPLA SGRLGQCLHT IQTEDRVWSI AISPLLSSFV TGTACCGHFS PLRIWDLNSG QLMTHLGSDF PPGAGVLDVM YESPFTLLSC GYDTYVRYWD LRTSVRKCVM EWEEPHDSTL YCLQTDGNHL LATGSSYYGV VRLWDRRQRA CLHAFPLTST PLSSPVYCLR LTTKHLYAAL SYNLHVLDFQ NP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards