Sestrin-2 (SESN2)

About Sestrin-2

Sestrin-2 (SESN2) is a protein from Homo sapiens identified by UniProt accession P58004, 480 residues long. MolForge cross-references it against 0 known binders and 239 disease associations.

Target properties

Protein name	Sestrin-2
UniProt accession	P58004
Gene	SESN2
Organism	Homo sapiens
Length	480 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (239)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.32
eosinophil count · score 0.23
breast adenocarcinoma · score 0.23
head and neck squamous cell carcinoma · score 0.19
endometrial cancer · score 0.18
squamous cell lung carcinoma · score 0.18
lung adenocarcinoma · score 0.18
eosinophil percentage of leukocytes · score 0.16
neoplasm · score 0.10
hepatocellular carcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58004-F1	alphafold	PREDICTED	81.37	—

Amino-acid sequence (480 residues)

MIVADSECRA ELKDYLRFAP GGVGDSGPGE EQRESRARRG PRGPSAFIPV EEVLREGAES LEQHLGLEAL MSSGRVDNLA VVMGLHPDYF TSFWRLHYLL LHTDGPLASS WRHYIAIMAA ARHQCSYLVG SHMAEFLQTG GDPEWLLGLH RAPEKLRKLS EINKLLAHRP WLITKEHIQA LLKTGEHTWS LAELIQALVL LTHCHSLSSF VFGCGILPEG DADGSPAPQA PTPPSEQSSP PSRDPLNNSG GFESARDVEA LMERMQQLQE SLLRDEGTSQ EEMESRFELE KSESLLVTPS ADILEPSPHP DMLCFVEDPT FGYEDFTRRG AQAPPTFRAQ DYTWEDHGYS LIQRLYPEGG QLLDEKFQAA YSLTYNTIAM HSGVDTSVLR RAIWNYIHCV FGIRYDDYDY GEVNQLLERN LKVYIKTVAC YPEKTTRRMY NLFWRHFRHS EKVHVNLLLL EARMQAALLY ALRAITRYMT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards