Forkhead box protein L2 (FOXL2)

About Forkhead box protein L2

Forkhead box protein L2 (FOXL2) is a protein from Homo sapiens identified by UniProt accession P58012, 376 residues long. MolForge cross-references it against 0 known binders and 273 disease associations.

Target properties

Protein name	Forkhead box protein L2
UniProt accession	P58012
Gene	FOXL2
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (273)

Diseases linked to this target (Open Targets).

blepharophimosis, ptosis, and epicanthus inversus syndrome · score 0.83
primary ovarian insufficiency · score 0.72
blepharophimosis-ptosis-epicanthus inversus syndrome type 2 · score 0.60
genetic non-acquired premature ovarian failure · score 0.44
genetic disorder · score 0.41
Ovarian Granulosa Cell Tumor · score 0.37
ovarian epithelial tumor · score 0.37
Ovarian Sertoli-Leydig Cell Tumor · score 0.37
neurodegenerative disease · score 0.34
non-small cell lung carcinoma · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58012-F1	alphafold	PREDICTED	60.13	—

Amino-acid sequence (376 residues)

MMASYPEPED AAGALLAPET GRTVKEPEGP PPSPGKGGGG GGGTAPEKPD PAQKPPYSYV ALIAMAIRES AEKRLTLSGI YQYIIAKFPF YEKNKKGWQN SIRHNLSLNE CFIKVPREGG GERKGNYWTL DPACEDMFEK GNYRRRRRMK RPFRPPPAHF QPGKGLFGAG GAAGGCGVAG AGADGYGYLA PPKYLQSGFL NNSWPLPQPP SPMPYASCQM AAAAAAAAAA AAAAGPGSPG AAAVVKGLAG PAASYGPYTR VQSMALPPGV VNSYNGLGGP PAAPPPPPHP HPHPHAHHLH AAAAPPPAPP HHGAAAPPPG QLSPASPATA APPAPAPTSA PGLQFACARQ PELAMMHCSY WDHDSKTGAL HSRLDL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards