About Lysyl oxidase homolog 3
Lysyl oxidase homolog 3 (LOXL3) is a protein
from Homo sapiens identified by UniProt accession
P58215, 753 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Lysyl oxidase homolog 3 |
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| UniProt accession | P58215 |
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| Gene | LOXL3 |
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| Organism | Homo sapiens |
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| Length | 753 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (117)
Diseases linked to this target (Open Targets).
- myopia 28, autosomal recessive · score 0.55
- 3-methylglutaconic aciduria type 8 · score 0.42
- 3-methylglutaconic aciduria · score 0.42
- Stickler syndrome · score 0.39
- neurodegenerative disease · score 0.37
- breast adenocarcinoma · score 0.23
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.18
- Young adult-onset Parkinsonism · score 0.18
- endometrial cancer · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P58215-F1 | alphafold | PREDICTED | 84.02 | — |
Amino-acid sequence (753 residues)
MRPVSVWQWS PWGLLLCLLC SSCLGSPSPS TGPEKKAGSQ GLRFRLAGFP RKPYEGRVEI QRAGEWGTIC DDDFTLQAAH ILCRELGFTE ATGWTHSAKY GPGTGRIWLD NLSCSGTEQS VTECASRGWG NSDCTHDEDA GVICKDQRLP GFSDSNVIEV EHHLQVEEVR IRPAVGWGRR PLPVTEGLVE VRLPDGWSQV CDKGWSAHNS HVVCGMLGFP SEKRVNAAFY RLLAQRQQHS FGLHGVACVG TEAHLSLCSL EFYRANDTAR CPGGGPAVVS CVPGPVYAAS SGQKKQQQSK PQGEARVRLK GGAHPGEGRV EVLKASTWGT VCDRKWDLHA ASVVCRELGF GSAREALSGA RMGQGMGAIH LSEVRCSGQE LSLWKCPHKN ITAEDCSHSQ DAGVRCNLPY TGAETRIRLS GGRSQHEGRV EVQIGGPGPL RWGLICGDDW GTLEAMVACR QLGLGYANHG LQETWYWDSG NITEVVMSGV RCTGTELSLD QCAHHGTHIT CKRTGTRFTA GVICSETASD LLLHSALVQE TAYIEDRPLH MLYCAAEENC LASSARSANW PYGHRRLLRF SSQIHNLGRA DFRPKAGRHS WVWHECHGHY HSMDIFTHYD ILTPNGTKVA EGHKASFCLE DTECQEDVSK RYECANFGEQ GITVGCWDLY RHDIDCQWID ITDVKPGNYI LQVVINPNFE VAESDFTNNA MKCNCKYDGH RIWVHNCHIG DAFSEEANRR FERYPGQTSN QII
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