Prokineticin-1 (PROK1)

About Prokineticin-1

Prokineticin-1 (PROK1) is a protein from Homo sapiens identified by UniProt accession P58294, 105 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.

Target properties

Protein name	Prokineticin-1
UniProt accession	P58294
Gene	PROK1
Organism	Homo sapiens
Length	105 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (74)

Diseases linked to this target (Open Targets).

Hirschsprung disease · score 0.37
breast adenocarcinoma · score 0.25
carotid artery intima media thickness · score 0.18
head and neck squamous cell carcinoma · score 0.16
adolescent idiopathic scoliosis · score 0.12
neoplasm · score 0.09
polycystic ovary syndrome · score 0.07
infect · score 0.07
infection · score 0.07
cancer · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58294-F1	alphafold	PREDICTED	90.02	—

Amino-acid sequence (105 residues)

MRGATRVSIM LLLVTVSDCA VITGACERDV QCGAGTCCAI SLWLRGLRMC TPLGREGEEC HPGSHKVPFF RKRKHHTCPC LPNLLCSRFP DGRYRCSMDL KNINF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards