Visual system homeobox 2 (VSX2)

About Visual system homeobox 2

Visual system homeobox 2 (VSX2) is a protein from Homo sapiens identified by UniProt accession P58304, 361 residues long. MolForge cross-references it against 0 known binders and 279 disease associations.

Target properties

Protein name	Visual system homeobox 2
UniProt accession	P58304
Gene	VSX2
Organism	Homo sapiens
Length	361 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (279)

Diseases linked to this target (Open Targets).

Isolated anophthalmia - microphthalmia · score 0.75
microphthalmia · score 0.54
microphthalmia, isolated, with coloboma · score 0.54
anophthalmia-microphthalmia syndrome · score 0.43
EDICT syndrome · score 0.42
retinitis pigmentosa · score 0.38
Anophthalmia · score 0.34
genetic disorder · score 0.19
nanophthalmia · score 0.10
X-linked retinal dysplasia · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58304-F1	alphafold	PREDICTED	60.23	—

Amino-acid sequence (361 residues)

MTGKAGEALS KPKSETVAKS TSGGAPARCT GFGIQEILGL NKEPPSSHPR AALDGLAPGH LLAARSVLSP AGVGGMGLLG PGGLPGFYTQ PTFLEVLSDP QSVHLQPLGR ASGPLDTSQT ASSDSEDVSS SDRKMSKSAL NQTKKRKKRR HRTIFTSYQL EELEKAFNEA HYPDVYAREM LAMKTELPED RIQVWFQNRR AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESILKSA KDGIMDSCAP WLLGMHKKSL EAAAESGRKP EGERQALPKL DKMEQDERGP DAQAAISQEE LRENSIAVLR AKAQEHSTKV LGTVSGPDSL ARSTEKPEEE EAMDEDRPAE RLSPPQLEDM A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards