Anthrax toxin receptor 2 (ANTXR2)

About Anthrax toxin receptor 2

Anthrax toxin receptor 2 (ANTXR2) is a protein from Homo sapiens identified by UniProt accession P58335, 489 residues long. MolForge cross-references it against 0 known binders and 222 disease associations.

Target properties

Protein name	Anthrax toxin receptor 2
UniProt accession	P58335
Gene	ANTXR2
Organism	Homo sapiens
Length	489 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (222)

Diseases linked to this target (Open Targets).

hyaline fibromatosis syndrome · score 0.80
anthrax infection · score 0.56
lymphocyte count · score 0.48
juvenile hyaline fibromatosis · score 0.46
leukocyte count · score 0.44
Myopia · score 0.38
age at onset · score 0.37
infantile systemic hyalinosis · score 0.37
refractive error · score 0.37
lymphocyte percentage of leukocytes · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58335-F1	alphafold	PREDICTED	71.82	—

Amino-acid sequence (489 residues)

MVAERSPARS PGSWLFPGLW LLVLSGPGGL LRAQEQPSCR RAFDLYFVLD KSGSVANNWI EIYNFVQQLA ERFVSPEMRL SFIVFSSQAT IILPLTGDRG KISKGLEDLK RVSPVGETYI HEGLKLANEQ IQKAGGLKTS SIIIALTDGK LDGLVPSYAE KEAKISRSLG ASVYCVGVLD FEQAQLERIA DSKEQVFPVK GGFQALKGII NSILAQSCTE ILELQPSSVC VGEEFQIVLS GRGFMLGSRN GSVLCTYTVN ETYTTSVKPV SVQLNSMLCP APILNKAGET LDVSVSFNGG KSVISGSLIV TATECSNGIA AIIVILVLLL LLGIGLMWWF WPLCCKVVIK DPPPPPAPAP KEEEEEPLPT KKWPTVDASY YGGRGVGGIK RMEVRWGDKG STEEGARLEK AKNAVVKIPE ETEEPIRPRP PRPKPTHQPP QTKWYTPIKG RLDALWALLR RQYDRVSLMR PQEGDEVCIW ECIEKELTA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards