Myeloid leukemia factor 1 (MLF1)

About Myeloid leukemia factor 1

Myeloid leukemia factor 1 (MLF1) is a protein from Homo sapiens identified by UniProt accession P58340, 268 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	Myeloid leukemia factor 1
UniProt accession	P58340
Gene	MLF1
Organism	Homo sapiens
Length	268 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

Uterine Carcinosarcoma · score 0.37
Endometrial Endometrioid Adenocarcinoma · score 0.37
Hepatobiliary Neoplasm · score 0.37
Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
gastric carcinoma · score 0.37
lung carcinoma · score 0.37
esophageal adenocarcinoma · score 0.37
lymphoid neoplasm · score 0.37
kidney neoplasm · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58340-F1	alphafold	PREDICTED	67.01	—

Amino-acid sequence (268 residues)

MFRMLNSSFE DDPFFSESIL AHRENMRQMI RSFSEPFGRD LLSISDGRGR AHNRRGHNDG EDSLTHTDVS SFQTMDQMVS NMRNYMQKLE RNFGQLSVDP NGHSFCSSSV MTYSKIGDEP PKVFQASTQT RRAPGGIKET RKAMRDSDSG LEKMAIGHHI HDRAHVIKKS KNKKTGDEEV NQEFINMNES DAHAFDEEWQ SEVLKYKPGR HNLGNTRMRS VGHENPGSRE LKRREKPQQS PAIEHGRRSN VLGDKLHIKG SSVKSNKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards