About Neurexin-1-beta
Neurexin-1-beta (NRXN1) is a protein
from Homo sapiens identified by UniProt accession
P58400, 472 residues long.
MolForge cross-references it against 0 known binders and
246 disease associations.
Target properties
| Protein name | Neurexin-1-beta |
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| UniProt accession | P58400 |
|---|
| Gene | NRXN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 472 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (246)
Diseases linked to this target (Open Targets).
- Pitt-Hopkins-like syndrome 2 · score 0.72
- chromosome 2p16.3 deletion syndrome · score 0.51
- autism spectrum disorder · score 0.49
- self reported educational attainment · score 0.46
- body mass index · score 0.43
- chronotype measurement · score 0.43
- Autism · score 0.42
- autism · score 0.42
- genetic disorder · score 0.42
- Intellectual disability · score 0.40
Amino-acid sequence (472 residues)
MYQRMLRCGA ELGSPGGGGG GGGGGGAGGR LALLWIVPLT LSGLLGVAWG ASSLGAHHIH HFHGSSKHHS VPIAIYRSPA SLRGGHAGTT YIFSKGGGQI TYKWPPNDRP STRADRLAIG FSTVQKEAVL VRVDSSSGLG DYLELHIHQG KIGVKFNVGT DDIAIEESNA IINDGKYHVV RFTRSGGNAT LQVDSWPVIE RYPAGNNDNE RLAIARQRIP YRLGRVVDEW LLDKGRQLTI FNSQATIIIG GKEQGQPFQG QLSGLYYNGL KVLNMAAEND ANIAIVGNVR LVGEVPSSMT TESTATAMQS EMSTSIMETT TTLATSTARR GKPPTKEPIS QTTDDILVAS AECPSDDEDI DPCEPSSGGL ANPTRAGGRE PYPGSAEVIR ESSSTTGMVV GIVAAAALCI LILLYAMYKY RNRDEGSYHV DESRNYISNS AQSNGAVVKE KQPSSAKSSN KNKKNKDKEY YV
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