Neurexophilin-1 (NXPH1)

About Neurexophilin-1

Neurexophilin-1 (NXPH1) is a protein from Homo sapiens identified by UniProt accession P58417, 271 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.

Target properties

Protein name	Neurexophilin-1
UniProt accession	P58417
Gene	NXPH1
Organism	Homo sapiens
Length	271 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (112)

Diseases linked to this target (Open Targets).

chronotype measurement · score 0.32
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.08
partial chromosome Y deletion · score 0.07
Rare genetic female infertility · score 0.07
spermatogenic failure 59 · score 0.07
spermatogenic failure 74 · score 0.07
spermatogenic failure 73 · score 0.07
spermatogenic failure 61 · score 0.07
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58417-F1	alphafold	PREDICTED	66.88	—

Amino-acid sequence (271 residues)

MQAACWYVLF LLQPTVYLVT CANLTNGGKS ELLKSGSSKS TLKHIWTESS KDLSISRLLS QTFRGKENDT DLDLRYDTPE PYSEQDLWDW LRNSTDLQEP RPRAKRRPIV KTGKFKKMFG WGDFHSNIKT VKLNLLITGK IVDHGNGTFS VYFRHNSTGQ GNVSVSLVPP TKIVEFDLAQ QTVIDAKDSK SFNCRIEYEK VDKATKNTLC NYDPSKTCYQ EQTQSHVSWL CSKPFKVICI YISFYSTDYK LVQKVCPDYN YHSDTPYFPS G

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards