About Clarin-1
Clarin-1 (CLRN1) is a protein
from Homo sapiens identified by UniProt accession
P58418, 232 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Clarin-1 |
|---|
| UniProt accession | P58418 |
|---|
| Gene | CLRN1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 232 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (90)
Diseases linked to this target (Open Targets).
- Usher syndrome type 3A · score 0.77
- retinitis pigmentosa · score 0.75
- Usher syndrome type 3 · score 0.70
- Retinal dystrophy · score 0.53
- Rare genetic deafness · score 0.53
- Usher syndrome · score 0.52
- hearing loss · score 0.37
- Hearing impairment · score 0.35
- neutrophil count · score 0.33
- myeloid white cell count · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P58418-F1 | alphafold | PREDICTED | 90.75 | — |
Amino-acid sequence (232 residues)
MPSQQKKIIF CMAGVFSFAC ALGVVTALGT PLWIKATVLC KTGALLVNAS GQELDKFMGE MQYGLFHGEG VRQCGLGARP FRFSFFPDLL KAIPVSIHVN VILFSAILIV LTMVGTAFFM YNAFGKPFET LHGPLGLYLL SFISGSCGCL VMILFASEVK IHHLSEKIAN YKEGTYVYKT QSEKYTTSFW VIFFCFFVHF LNGLLIRLAG FQFPFAKSKD AETTNVAADL MY
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