Myotrophin (MTPN)

About Myotrophin

Myotrophin (MTPN) is a protein from Homo sapiens identified by UniProt accession P58546, 118 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	Myotrophin
UniProt accession	P58546
Gene	MTPN
Organism	Homo sapiens
Length	118 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

platelet count · score 0.46
mean platelet volume · score 0.44
platelet component distribution width · score 0.41
cardiac hypertrophy · score 0.02
left ventricular hypertrophy · score 0.02
breast ductal carcinoma in situ · score 0.01
type 2 diabetes mellitus · score 0.01
acute coronary syndrome · score 0.01
Corpuscular Hemoglobin Content · score 0.01
Chédiak-Higashi syndrome · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58546-F1	alphafold	PREDICTED	88.22	—

Amino-acid sequence (118 residues)

MCDKEFMWAL KNGDLDEVKD YVAKGEDVNR TLEGGRKPLH YAADCGQLEI LEFLLLKGAD INAPDKHHIT PLLSAVYEGH VSCVKLLLSK GADKTVKGPD GLTAFEATDN QAIKALLQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards