Histone H2B type 1-D (H2BC5)

About Histone H2B type 1-D

Histone H2B type 1-D (H2BC5) is a protein from Homo sapiens identified by UniProt accession P58876, 126 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.

Target properties

Protein name	Histone H2B type 1-D
UniProt accession	P58876
Gene	H2BC5
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (89)

Diseases linked to this target (Open Targets).

viral disease · score 0.50
infectious disease · score 0.50
breast carcinoma · score 0.37
cancer · score 0.37
melanoma · score 0.37
C-reactive protein measurement · score 0.31
body fat percentage · score 0.29
BMI-adjusted waist circumference · score 0.28
body height · score 0.27
smoking status measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P58876-F1	alphafold	PREDICTED	87.78	—

Amino-acid sequence (126 residues)

MPEPTKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSV YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards