About NACHT, LRR and PYD domains-containing protein 11
NACHT, LRR and PYD domains-containing protein 11 (NLRP11) is a protein
from Homo sapiens identified by UniProt accession
P59045, 1033 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | NACHT, LRR and PYD domains-containing protein 11 |
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| UniProt accession | P59045 |
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| Gene | NLRP11 |
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| Organism | Homo sapiens |
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| Length | 1033 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- age at menopause · score 0.41
- birth weight · score 0.27
- parental genotype effect measurement · score 0.27
- menopause · score 0.19
- lung adenocarcinoma · score 0.07
- infect · score 0.05
- infection · score 0.05
- central nervous system cancer · score 0.04
- Down syndrome · score 0.02
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P59045-F1 | alphafold | PREDICTED | 85.22 | — |
Amino-acid sequence (1033 residues)
MAESDSTDFD LLWYLENLSD KEFQSFKKYL ARKILDFKLP QFPLIQMTKE ELANVLPISY EGQYIWNMLF SIFSMMRKED LCRKIIGRRN RNQEACKAVM RRKFMLQWES HTFGKFHYKF FRDVSSDVFY ILQLAYDSTS YYSANNLNVF LMGERASGKT IVINLAVLRW IKGEMWQNMI SYVVHLTAHE INQMTNSSLA ELIAKDWPDG QAPIADILSD PKKLLFILED LDNIRFELNV NESALCSNST QKVPIPVLLV SLLKRKMAPG CWFLISSRPT RGNNVKTFLK EVDCCTTLQL SNGKREIYFN SFFKDRQRAS AALQLVHEDE ILVGLCRVAI LCWITCTVLK RQMDKGRDFQ LCCQTPTDLH AHFLADALTS EAGLTANQYH LGLLKRLCLL AAGGLFLSTL NFSGEDLRCV GFTEADVSVL QAANILLPSN THKDRYKFIH LNVQEFCTAI AFLMAVPNYL IPSGSREYKE KREQYSDFNQ VFTFIFGLLN ANRRKILETS FGYQLPMVDS FKWYSVGYMK HLDRDPEKLT HHMPLFYCLY ENREEEFVKT IVDALMEVTV YLQSDKDMMV SLYCLDYCCH LRTLKLSVQR IFQNKEPLIR PTASQMKSLV YWREICSLFY TMESLRELHI FDNDLNGISE RILSKALEHS SCKLRTLKLS YVSTASGFED LLKALARNRS LTYLSINCTS ISLNMFSLLH DILHEPTCQI SHLSLMKCDL RASECEEIAS LLISGGSLRK LTLSSNPLRS DGMNILCDAL LHPNCTLISL VLVFCCLTEN CCSALGRVLL FSPTLRQLDL CVNRLKNYGV LHVTFPLLFP TCQLEELHLS GCFFSSDICQ YIAIVIATNE KLRSLEIGSN KIEDAGMQLL CGGLRHPNCM LVNIGLEECM LTSACCRSLA SVLTTNKTLE RLNLLQNHLG NDGVAKLLES LISPDCVLKV VGLPLTGLNT QTQQLLMTVK ERKPSLIFLS ETWSLKEGRE IGVTPASQPG SIIPNSNLDY MFFKFPRMSA AMRTSNTASR QPL
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