About Tubulin polymerization-promoting protein family member 2
Tubulin polymerization-promoting protein family member 2 (TPPP2) is a protein
from Homo sapiens identified by UniProt accession
P59282, 170 residues long.
MolForge cross-references it against 0 known binders and
81 disease associations.
Target properties
| Protein name | Tubulin polymerization-promoting protein family member 2 |
|---|
| UniProt accession | P59282 |
|---|
| Gene | TPPP2 |
|---|
| Organism | Homo sapiens |
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| Length | 170 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (81)
Diseases linked to this target (Open Targets).
- urticaria · score 0.13
- amino acid measurement · score 0.11
- protein measurement · score 0.11
- blood metabolite measurement · score 0.11
- azoospermia · score 0.08
- attention deficit-hyperactivity disorder 8 · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- schizophrenia 15 · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P59282-F1 | alphafold | PREDICTED | 84.98 | — |
Amino-acid sequence (170 residues)
MASEAEKTFH RFAAFGESSS SGTEMNNKNF SKLCKDCGIM DGKTVTSTDV DIVFSKVKAK NARTITFQQF KEAVKELGQK RFKGKSPDEV LENIYGLMEG KDPATTGATK ATTVGAVDRL TDTSKYTGTH KERFDESGKG KGIAGREEMT DNTGYVSGYK GSGTYDKKTK
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