Taste receptor type 2 member 38 (TAS2R38)

About Taste receptor type 2 member 38

Taste receptor type 2 member 38 (TAS2R38) is a protein from Homo sapiens identified by UniProt accession P59533, 333 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Taste receptor type 2 member 38
UniProt accession	P59533
Gene	TAS2R38
Organism	Homo sapiens
Length	333 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (76)

Diseases linked to this target (Open Targets).

sensory perception of bitter taste · score 0.43
alcohol consumption measurement · score 0.28
diet measurement · score 0.23
tea consumption measurement · score 0.22
bitter alcoholic beverage consumption measurement · score 0.22
lung adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.16
squamous cell lung carcinoma · score 0.13
gastric adenocarcinoma · score 0.10
breast cancer · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59533-F1	alphafold	PREDICTED	82.23	—

Amino-acid sequence (333 residues)

MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL SNSDCVLLCL SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM IANQANLWLA ACLSLLYCSK LIRFSHTFLI CLASWVSRKI SQMLLGIILC SCICTVLCVW CFFSRPHFTV TTVLFMNNNT RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE AHIKALKSLV SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards