Taste receptor type 2 member 39 (TAS2R39)

About Taste receptor type 2 member 39

Taste receptor type 2 member 39 (TAS2R39) is a protein from Homo sapiens identified by UniProt accession P59534, 338 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.

Target properties

Protein name	Taste receptor type 2 member 39
UniProt accession	P59534
Gene	TAS2R39
Organism	Homo sapiens
Length	338 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (19)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.22
lung adenocarcinoma · score 0.18
blood protein measurement · score 0.13
squamous cell lung carcinoma · score 0.13
head and neck squamous cell carcinoma · score 0.13
neuroblastoma · score 0.11
46,XY complete gonadal dysgenesis · score 0.05
Testicular regression syndrome · score 0.04
isolated congenital hypogonadotropic hypogonadism · score 0.04
46,XX testicular disorder of sex development · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59534-F1	alphafold	PREDICTED	81.25	—

Amino-acid sequence (338 residues)

MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII ANGFIMAIHA AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS LSFYSEDAVY YAFKISFIFL NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL RWRITGLIPW LLWLSVFISF SHSMFCINIC TVYCNNSFPI HSSNSTKKTY LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL HMGSNATGSN DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards