Taste receptor type 2 member 40 (TAS2R40)

About Taste receptor type 2 member 40

Taste receptor type 2 member 40 (TAS2R40) is a protein from Homo sapiens identified by UniProt accession P59535, 323 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Taste receptor type 2 member 40
UniProt accession	P59535
Gene	TAS2R40
Organism	Homo sapiens
Length	323 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (7)

Diseases linked to this target (Open Targets).

lung adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.16
squamous cell lung carcinoma · score 0.13
medulloblastoma · score 0.13
head and neck squamous cell carcinoma · score 0.13
gastric adenocarcinoma · score 0.10
small cell lung carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59535-F1	alphafold	PREDICTED	81.05	—

Amino-acid sequence (323 residues)

MATVNTDATD KDISKFKVTF TLVVSGIECI TGILGSGFIT AIYGAEWARG KTLPTGDRIM LMLSFSRLLL QIWMMLENIF SLLFRIVYNQ NSVYILFKVI TVFLNHSNLW FAAWLKVFYC LRIANFNHPL FFLMKRKIIV LMPWLLRLSV LVSLSFSFPL SRDVFNVYVN SSIPIPSSNS TEKKYFSETN MVNLVFFYNM GIFVPLIMFI LAATLLILSL KRHTLHMGSN ATGSRDPSMK AHIGAIKATS YFLILYIFNA IALFLSTSNI FDTYSSWNIL CKIIMAAYPA GHSVQLILGN PGLRRAWKRF QHQVPLYLKG QTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards