FXYD domain-containing ion transport regulator 4…

About FXYD domain-containing ion transport regulator 4

FXYD domain-containing ion transport regulator 4 (FXYD4) is a protein from Homo sapiens identified by UniProt accession P59646, 89 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	FXYD domain-containing ion transport regulator 4
UniProt accession	P59646
Gene	FXYD4
Organism	Homo sapiens
Length	89 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

blood urea nitrogen measurement · score 0.35
cystatin C measurement · score 0.28
breast adenocarcinoma · score 0.25
Hirschsprung disease · score 0.19
platelet count · score 0.18
eosinophil count · score 0.18
HbA1c measurement · score 0.10
eosinophil percentage of leukocytes · score 0.06
clear cell renal carcinoma · score 0.06
nephronophthisis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59646-F1	alphafold	PREDICTED	70.06	—

Amino-acid sequence (89 residues)

MERVTLALLL LAGLTALEAN DPFANKDDPF YYDWKNLQLS GLICGGLLAI AGIAAVLSGK CKCKSSQKQH SPVPEKAIPL ITPGSATTC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

FXYD domain-containing ion transport regulator 4 (FXYD4)