Neutrophil defensin 1 (DEFA1)

About Neutrophil defensin 1

Neutrophil defensin 1 (DEFA1) is a protein from Homo sapiens identified by UniProt accession P59665, 94 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Neutrophil defensin 1
UniProt accession	P59665
Gene	DEFA1
Organism	Homo sapiens
Length	94 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

monocyte percentage of leukocytes · score 0.35
basophil percentage of leukocytes · score 0.32
monocyte count · score 0.28
basophil count · score 0.27
IGA glomerulonephritis · score 0.26
granulocyte percentage of myeloid white cells · score 0.26
blood protein measurement · score 0.25
basophil percentage of granulocytes · score 0.18
neutrophil count · score 0.03
neoplasm of mature B-cells · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59665-F1	alphafold	PREDICTED	73.36	—

Amino-acid sequence (94 residues)

MRTLAILAAI LLVALQAQAE PLQARADEVA AAPEQIAADI PEVVVSLAWD ESLAPKHPGS RKNMACYCRI PACIAGERRY GTCIYQGRLW AFCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards