Neutrophil defensin 3 (DEFA3)

About Neutrophil defensin 3

Neutrophil defensin 3 (DEFA3) is a protein from Homo sapiens identified by UniProt accession P59666, 94 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.

Target properties

Protein name	Neutrophil defensin 3
UniProt accession	P59666
Gene	DEFA3
Organism	Homo sapiens
Length	94 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (81)

Diseases linked to this target (Open Targets).

monocyte count · score 0.36
monocyte percentage of leukocytes · score 0.34
basophil count · score 0.34
basophil percentage of leukocytes · score 0.32
blood protein measurement · score 0.30
granulocyte percentage of myeloid white cells · score 0.28
lymphocyte:monocyte ratio · score 0.23
cutaneous melanoma · score 0.22
mitochondrial DNA measurement · score 0.20
IGA glomerulonephritis · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59666-F1	alphafold	PREDICTED	73.49	—

Amino-acid sequence (94 residues)

MRTLAILAAI LLVALQAQAE PLQARADEVA AAPEQIAADI PEVVVSLAWD ESLAPKHPGS RKNMDCYCRI PACIAGERRY GTCIYQGRLW AFCC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards