Guanine nucleotide-binding protein G(I)/G(S)/G(O)…

About Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (GNG2) is a protein from Homo sapiens identified by UniProt accession P59768, 71 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
UniProt accession	P59768
Gene	GNG2
Organism	Homo sapiens
Length	71 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

BMI-adjusted waist circumference · score 0.34
multiple sclerosis · score 0.32
glioblastoma multiforme · score 0.28
endometrial cancer · score 0.28
head and neck squamous cell carcinoma · score 0.26
lung adenocarcinoma · score 0.23
high density lipoprotein cholesterol measurement · score 0.23
urinary bladder cancer · score 0.20
drug use measurement · score 0.08
breast cancer · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59768-F1	alphafold	PREDICTED	89.56	—

Amino-acid sequence (71 residues)

MASNNTASIA QARKLVEQLK MEANIDRIKV SKAAADLMAY CEAHAKEDPL LTPVPASENP FREKKFFCAI L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (GNG2)