Major intrinsically disordered NOTCH2-binding…

About Major intrinsically disordered NOTCH2-binding receptor 1-like

Major intrinsically disordered NOTCH2-binding receptor 1-like (MINAR2) is a protein from Homo sapiens identified by UniProt accession P59773, 190 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	Major intrinsically disordered NOTCH2-binding receptor 1-like
UniProt accession	P59773
Gene	MINAR2
Organism	Homo sapiens
Length	190 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

refractive error measurement · score 0.46
hearing loss, autosomal recessive · score 0.37
corneal topography · score 0.34
body height · score 0.30
appendicular lean mass · score 0.29
lean body mass · score 0.27
forced expiratory volume · score 0.24
BMI-adjusted hip circumference · score 0.23
cortical surface area measurement · score 0.23
vital capacity · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59773-F1	alphafold	PREDICTED	62.39	—

Amino-acid sequence (190 residues)

MDLSVLPNNN HPDKFLQLDV KSLTRSSALL QASLVRFPGG NYPAAQHWQN LVYSQREKKN IAAQRIRGSS ADSLVTADSP PPSMSSVMKN NPLYGDLSLE EAMEERKKNP SWTIEEYDKH SLHTNLSGHL KENPNDLRFW LGDMYTPGFD TLLKKEEKQE KHSKFCRMGL ILLVVISILV TIVTIITFFT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Major intrinsically disordered NOTCH2-binding receptor 1-like (MINAR2)