About AP-3 complex subunit sigma-2
AP-3 complex subunit sigma-2 (AP3S2) is a protein
from Homo sapiens identified by UniProt accession
P59780, 193 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | AP-3 complex subunit sigma-2 |
|---|
| UniProt accession | P59780 |
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| Gene | AP3S2 |
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| Organism | Homo sapiens |
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| Length | 193 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.28
- HbA1c measurement · score 0.19
- diabetes mellitus · score 0.19
- Drugs used in diabetes use measurement · score 0.17
- prostate carcinoma · score 0.13
- hemoglobin A1 measurement · score 0.12
- attention deficit hyperactivity disorder · score 0.04
- schizophrenia 15 · score 0.03
- Phelan-McDermid syndrome · score 0.03
- hepatocellular carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P59780-F1 | alphafold | PREDICTED | 81.81 | — |
Amino-acid sequence (193 residues)
MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL EGGSLIGGSD YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHMDKVHYIL QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS EGGLSAAPAR AVSAVKNINL PEIPRNINIG DLNIKVPNLS QFV
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