About BPI fold-containing family B member 4
BPI fold-containing family B member 4 (BPIFB4) is a protein
from Homo sapiens identified by UniProt accession
P59827, 614 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | BPI fold-containing family B member 4 |
|---|
| UniProt accession | P59827 |
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| Gene | BPIFB4 |
|---|
| Organism | Homo sapiens |
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| Length | 614 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.30
- lung adenocarcinoma · score 0.18
- endometrial cancer · score 0.15
- squamous cell lung carcinoma · score 0.14
- head and neck squamous cell carcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- COVID-19 · score 0.08
- Mobius syndrome · score 0.07
- Huntington disease · score 0.06
- glioblastoma multiforme · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P59827-F1 | alphafold | PREDICTED | 68.35 | — |
Amino-acid sequence (614 residues)
MWMAWCVAAL SVVAVCGTSH ETNTVLRVTK DVLSNAISGM LQQSDALHSA LREVPLGVGD IPYNDFHVRG PPPVYTNGKK LDGIYQYGHI ETNDNTAQLG GKYRYGEILE SEGSIRDLRN SGYRSAENAY GGHRGLGRYR AAPVGRLHRR ELQPGEIPPG VATGAVGPGG LLGTGGMLAA DGILAGQGGL LGGGGLLGDG GLLGGGGVLG VLGEGGILST VQGITGLRIV ELTLPRVSVR LLPGVGVYLS LYTRVAINGK SLIGFLDIAV EVNITAKVRL TMDRTGYPRL VIERCDTLLG GIKVKLLRGL LPNLVDNLVN RVLADVLPDL LCPIVDVVLG LVNDQLGLVD SLIPLGILGS VQYTFSSLPL VTGEFLELDL NTLVGEAGGG LIDYPLGWPA VSPKPMPELP PMGDNTKSQL AMSANFLGSV LTLLQKQHAL DLDITNGMFE ELPPLTTATL GALIPKVFQQ YPESCPLIIR IQVLNPPSVM LQKDKALVKV LATAEVMVSQ PKDLETTICL IDVDTEFLAS FSTEGDKLMI DAKLEKTSLN LRTSNVGNFD IGLMEVLVEK IFDLAFMPAM NAVLGSGVPL PKILNIDFSN ADIDVLEDLL VLSA
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