Beta-defensin 131A (DEFB131A)

About Beta-defensin 131A

Beta-defensin 131A (DEFB131A) is a protein from Homo sapiens identified by UniProt accession P59861, 70 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Beta-defensin 131A
UniProt accession	P59861
Gene	DEFB131A
Organism	Homo sapiens
Length	70 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

urate measurement · score 0.27
opioid use disorder · score 0.27
creatinine measurement · score 0.21
drug use measurement · score 0.15
gout · score 0.09
red blood cell density measurement · score 0.05
deafness · score 0.05
Alzheimer disease · score 0.02
age at onset · score 0.02
Hepatitis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P59861-F1	alphafold	PREDICTED	70.24	—

Amino-acid sequence (70 residues)

MRVLFFVFGV LSLMFTVPPA RSFISNDECP SEYYHCRLKC NADEHAIRYC ADFSICCKLK IIEIDGQKKW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards