About Actin-related protein 2/3 complex subunit 4
Actin-related protein 2/3 complex subunit 4 (ARPC4) is a protein
from Homo sapiens identified by UniProt accession
P59998, 168 residues long.
MolForge cross-references it against 0 known binders and
102 disease associations.
Target properties
| Protein name | Actin-related protein 2/3 complex subunit 4 |
|---|
| UniProt accession | P59998 |
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| Gene | ARPC4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 168 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (102)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- developmental delay, language impairment, and ocular abnormalities · score 0.49
- Microcephaly · score 0.37
- microcephaly · score 0.37
- cutaneous Leishmaniasis · score 0.37
- lysosomal storage disease · score 0.35
- Alzheimer disease · score 0.35
- Parkinson disease · score 0.35
- multiple sclerosis · score 0.35
- genetic disorder · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P59998-F1 | alphafold | PREDICTED | 94.29 | — |
Amino-acid sequence (168 residues)
MTATLRPYLS AVRATLQAAL CLENFSSQVV ERHNKPEVEV RSSKELLLQP VTISRNEKEK VLIEGSINSV RVSIAVKQAD EIEKILCHKF MRFMMMRAEN FFILRRKPVE GYDISFLITN FHTEQMYKHK LVDFVIHFME EIDKEISEMK LSVNARARIV AEEFLKNF
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