Anaphase-promoting complex subunit 15 (ANAPC15)

About Anaphase-promoting complex subunit 15

Anaphase-promoting complex subunit 15 (ANAPC15) is a protein from Homo sapiens identified by UniProt accession P60006, 121 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Anaphase-promoting complex subunit 15
UniProt accession	P60006
Gene	ANAPC15
Organism	Homo sapiens
Length	121 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

deafness · score 0.48
autosomal recessive nonsyndromic hearing loss 63 · score 0.48
genetic disorder · score 0.41
endometrial cancer · score 0.18
hearing loss, autosomal recessive · score 0.17
hypertriglyceridemia 2 · score 0.06
cholesterol-ester transfer protein deficiency · score 0.05
Combined hyperlipidemia · score 0.04
influenza A (H1N1) · score 0.04
thyroid hormone metabolism, abnormal, 2 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60006-F1	alphafold	PREDICTED	70.92	—

Amino-acid sequence (121 residues)

MSTLFPSLFP RVTETLWFNL DRPCVEETEL QQQEQQHQAW LQSIAEKDNN LVPIGKPASE HYDDEEEEDD EDDEDSEEDS EDDEDMQDMD EMNDYNESPD DGEVNEVDME GNEQDQDQWM I

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards