Beta-defensin 1 (DEFB1)

About Beta-defensin 1

Beta-defensin 1 (DEFB1) is a protein from Homo sapiens identified by UniProt accession P60022, 68 residues long. MolForge cross-references it against 0 known binders and 326 disease associations.

Target properties

Protein name	Beta-defensin 1
UniProt accession	P60022
Gene	DEFB1
Organism	Homo sapiens
Length	68 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (326)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.36
cutaneous melanoma · score 0.23
viral load · score 0.18
squamous cell lung carcinoma · score 0.17
basophil count · score 0.10
breast adenocarcinoma · score 0.10
oral squamous cell carcinoma · score 0.10
Immunodeficiency due to a late component of complements deficiency · score 0.10
immunodeficiency 28 · score 0.09
chronic obstructive pulmonary disease · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60022-F1	alphafold	PREDICTED	81.33	—

Amino-acid sequence (68 residues)

MRTSYLLLFT LCLLLSEMAS GGNFLTGLGH RSDHYNCVSS GGQCLYSACP IFTKIQGTCY RGKAKCCK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards