About Inactive ribonuclease-like protein 9
Inactive ribonuclease-like protein 9 (RNASE9) is a protein
from Homo sapiens identified by UniProt accession
P60153, 205 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Inactive ribonuclease-like protein 9 |
|---|
| UniProt accession | P60153 |
|---|
| Gene | RNASE9 |
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| Organism | Homo sapiens |
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| Length | 205 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 7 · score 0.06
- spermatogenic failure 55 · score 0.06
- spermatogenic failure 3 · score 0.06
- spermatogenic failure 19 · score 0.06
- spermatogenic failure 43 · score 0.06
- spermatogenic failure 49 · score 0.06
- spermatogenic failure 45 · score 0.06
- spermatogenic failure 10 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60153-F1 | alphafold | PREDICTED | 80.76 | — |
Amino-acid sequence (205 residues)
MMRTLITTHP LPLLLLPQQL LQLVQFQEVD TDFDFPEEDK KEEFEECLEK FFSTGPARPP TKEKVKRRVL IEPGMPLNHI EYCNHEIMGK NVYYKHRWVA EHYFLLMQYD ELQKICYNRF VPCKNGIRKC NRSKGLVEGV YCNLTEAFEI PACKYESLYR KGYVLITCSW QNEMQKRIPH TINDLVEPPE HRSFLSEDGV FVISP
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