About Triosephosphate isomerase
Triosephosphate isomerase (TPI1) is a protein
from Homo sapiens identified by UniProt accession
P60174, 249 residues long.
MolForge cross-references it against 0 known binders and
453 disease associations.
Target properties
| Protein name | Triosephosphate isomerase |
|---|
| UniProt accession | P60174 |
|---|
| Gene | TPI1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 249 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (453)
Diseases linked to this target (Open Targets).
- triosephosphate isomerase deficiency · score 0.75
- Triose phosphate-isomerase deficiency · score 0.67
- neurodegenerative disease · score 0.37
- genetic disorder · score 0.18
- blood protein measurement · score 0.17
- endometrial cancer · score 0.12
- neoplasm · score 0.10
- lung adenocarcinoma · score 0.10
- Blackfan-Diamond anemia · score 0.09
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60174-F1 | alphafold | PREDICTED | 96.66 | — |
Amino-acid sequence (249 residues)
MAPSRKFFVG GNWKMNGRKQ SLGELIGTLN AAKVPADTEV VCAPPTAYID FARQKLDPKI AVAAQNCYKV TNGAFTGEIS PGMIKDCGAT WVVLGHSERR HVFGESDELI GQKVAHALAE GLGVIACIGE KLDEREAGIT EKVVFEQTKV IADNVKDWSK VVLAYEPVWA IGTGKTATPQ QAQEVHEKLR GWLKSNVSDA VAQSTRIIYG GSVTGATCKE LASQPDVDGF LVGGASLKPE FVDIINAKQ
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