Myelin proteolipid protein (PLP1)

About Myelin proteolipid protein

Myelin proteolipid protein (PLP1) is a protein from Homo sapiens identified by UniProt accession P60201, 277 residues long. MolForge cross-references it against 0 known binders and 487 disease associations.

Target properties

Protein name	Myelin proteolipid protein
UniProt accession	P60201
Gene	PLP1
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (487)

Diseases linked to this target (Open Targets).

Pelizeaus-Merzbacher spectrum disorder · score 0.84
Spastic paraplegia type 2 · score 0.82
hereditary spastic paraplegia 2 · score 0.81
Sudanophilic leukodystrophy · score 0.55
Pelizaeus-Merzbacher disease, connatal form · score 0.51
genetic disorder · score 0.50
hereditary spastic paraplegia · score 0.39
null syndrome · score 0.39
Pelizaeus-Merzbacher disease, transitional form · score 0.38
Pelizaeus-Merzbacher disease, classic form · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60201-F1	alphafold	PREDICTED	77.46	—

Amino-acid sequence (277 residues)

MGLLECCARC LVGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEKLIETY FSKNYQDYEY LINVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI FGDYKTTICG KGLSATVTGG QKGRGSRGQH QAHSLERVCH CLGKWLGHPD KFVGITYALT VVWLLVFACS AVPVYIYFNT WTTCQSIAFP SKTSASIGSL CADARMYGVL PWNAFPGKVC GSNLLSICKT AEFQMTFHLF IAAFVGAAAT LVSLLTFMIA ATYNFAVLKL MGRGTKF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards