About Eukaryotic translation initiation factor 3 subunit E
Eukaryotic translation initiation factor 3 subunit E (EIF3E) is a protein
from Homo sapiens identified by UniProt accession
P60228, 445 residues long.
MolForge cross-references it against 0 known binders and
135 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 3 subunit E |
|---|
| UniProt accession | P60228 |
|---|
| Gene | EIF3E |
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| Organism | Homo sapiens |
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| Length | 445 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (135)
Diseases linked to this target (Open Targets).
- head and neck squamous cell carcinoma · score 0.37
- colon adenocarcinoma · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
- pancreatic carcinoma · score 0.37
- bile duct carcinoma · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- breast ductal adenocarcinoma · score 0.37
- esophageal adenocarcinoma · score 0.37
- FEV/FVC ratio · score 0.30
- cervical squamous cell carcinoma · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60228-F1 | alphafold | PREDICTED | 64.86 | — |
Amino-acid sequence (445 residues)
MAEYDLTTRI AHFLDRHLVF PLLEFLSVKE IYNEKELLQG KLDLLSDTNM VDFAMDVYKN LYSDDIPHAL REKRTTVVAQ LKQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA TDRNALSSLW GKLASEILMQ NWDAAMEDLT RLKETIDNNS VSSPLQSLQQ RTWLIHWSLF VFFNHPKGRD NIIDLFLYQP QYLNAIQTMC PHILRYLTTA VITNKDVRKR RQVLKDLVKV IQQESYTYKD PITEFVECLY VNFDFDGAQK KLRECESVLV NDFFLVACLE DFIENARLFI FETFCRIHQC ISINMLADKL NMTPEEAERW IVNLIRNARL DAKIDSKLGH VVMGNNAVSP YQQVIEKTKS LSFRSQMLAM NIEKKLNQNS RSEAPNWATQ DSGFY
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