About Nanos homolog 2
Nanos homolog 2 (NANOS2) is a protein
from Homo sapiens identified by UniProt accession
P60321, 138 residues long.
MolForge cross-references it against 0 known binders and
199 disease associations.
Target properties
| Protein name | Nanos homolog 2 |
|---|
| UniProt accession | P60321 |
|---|
| Gene | NANOS2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 138 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (199)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- hematocrit · score 0.17
- neuroticism measurement · score 0.16
- azoospermia · score 0.11
- male infertility with teratozoospermia due to single gene mutation · score 0.10
- partial chromosome Y deletion · score 0.10
- spermatogenic failures 50 · score 0.10
- spermatogenic failure 25 · score 0.09
- spermatogenic failure 61 · score 0.09
- spermatogenic failure, X-linked, 2 · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60321-F1 | alphafold | PREDICTED | 75.58 | — |
Amino-acid sequence (138 residues)
MQLPPFDMWK DYFNLSQVVW ALIASRGQRL ETQEIEEPSP GPPLGQDQGL GAPGANGGLG TLCNFCKHNG ESRHVYSSHQ LKTPDGVVVC PILRHYVCPV CGATGDQAHT LKYCPLNGGQ QSLYRRSGRN SAGRRVKR
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