Keratin-associated protein 10-1 (KRTAP10-1)

About Keratin-associated protein 10-1

Keratin-associated protein 10-1 (KRTAP10-1) is a protein from Homo sapiens identified by UniProt accession P60331, 282 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Keratin-associated protein 10-1
UniProt accession	P60331
Gene	KRTAP10-1
Organism	Homo sapiens
Length	282 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.18
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
neuroblastoma · score 0.13
hearing loss, autosomal recessive · score 0.12
deafness · score 0.12
hair shape measurement · score 0.04
autosomal recessive hypohidrotic ectodermal dysplasia · score 0.01
osteosarcoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60331-F1	alphafold	PREDICTED	35.71	—

Amino-acid sequence (282 residues)

MAASTMSVCS SACSDSWQVD ACPESCCEPH CCALSCCAPA PCLTLVCTPV SRVSSPCCQA ACEPSPCQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC VPVCCKPVCC LPTCSKDSSS CCQQSSCQPT CCASSSSQQS CCVPVCCKPV CYVPTCSEDS SSCCQQSSCH PACCTSSPCQ QACCVPVRCK PVCCKPICCV PVCSGASTSC CQQSSCQPAC CTTSCCRPSS SVSLLCRPVC RPACCMPVSS CCAPASSCQA SCCRPASCVS LLCRPACSRP AC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards