Keratin-associated protein 10-4 (KRTAP10-4)

About Keratin-associated protein 10-4

Keratin-associated protein 10-4 (KRTAP10-4) is a protein from Homo sapiens identified by UniProt accession P60372, 401 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Keratin-associated protein 10-4
UniProt accession	P60372
Gene	KRTAP10-4
Organism	Homo sapiens
Length	401 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

head and neck squamous cell carcinoma · score 0.18
clear cell renal carcinoma · score 0.18
glioblastoma multiforme · score 0.18
prostate adenocarcinoma · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
attention deficit hyperactivity disorder · score 0.06
Tourette syndrome · score 0.05
schizophrenia 15 · score 0.04
Phelan-McDermid syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60372-F1	alphafold	PREDICTED	35.42	—

Amino-acid sequence (401 residues)

MSVCSSDLSY SSRVCLPGSC DSCSDSWQVD DCPESCCEPP CCAPSCCAPA PCLSLVCTPV SRVSSPCCPV TCEPSPCQSG CTSSCTPSCC QQSSCQLACC ASSPCQQACC VPVCCKTVCC KPVCCVPVCC GDSSCCQQSS CQSACCTSSP CQQACCVPIC CKPVCSGISS SCCQQSSCVS CVSSPCCQAV CEPSPCQSGC ISSCTPSCCQ QSSCQPACCT SSSCQQACCV PVCCKTVCCK PVCSEDSSSC CQQSSCQPAC CTSSPCQQAC CVPVCCKPVC CKPVCSVPIC SGASSLCCQQ SSCQPACCTS SQSQQGCCVP VCCKPVSCVP VCSGASSSCC QQSSCQPACC TTSCCRPSSS VSLLCRPVCR PACCVPVPSC CAPTSSCQPS CCRPASCVSL L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards