Keratin-associated protein 10-11 (KRTAP10-11)

About Keratin-associated protein 10-11

Keratin-associated protein 10-11 (KRTAP10-11) is a protein from Homo sapiens identified by UniProt accession P60412, 298 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.

Target properties

Protein name	Keratin-associated protein 10-11
UniProt accession	P60412
Gene	KRTAP10-11
Organism	Homo sapiens
Length	298 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (16)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.30
glioblastoma multiforme · score 0.19
ovarian cancer · score 0.18
breast adenocarcinoma · score 0.18
thyroid gland adenocarcinoma · score 0.16
esophageal cancer · score 0.14
myoepithelial tumor · score 0.11
attention deficit hyperactivity disorder · score 0.06
Tourette syndrome · score 0.05
schizophrenia 15 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60412-F1	alphafold	PREDICTED	36.08	—

Amino-acid sequence (298 residues)

MAASTMSVCS SAYSDSWQVD DCPESCCEPP CSAPSCCAPA PSLSLVCTPV SCVSSPCCQA ACEPSACQSG CTSSCTPSCC QQSSCQPACC TSSPCQQACC VPVCCKTVCC KPVCCVPVCC GAASSCCRQS SCQPACCASS SCQPACCVPV CCKPVCCVST CSEDSSSCCQ QSSCQPACCT SSSYQQACCV PVCCKTVYCK PICCVPVCSR ASSSRCQQPS CQPACCTTSC CRPSSSVSLL CHPVCRSTCC VPVSSCCAPT SSCQSSCCRP ASCVSLLCRP ASSRLACYSL CSGKKSSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards