About Keratin-associated protein 10-12
Keratin-associated protein 10-12 (KRTAP10-12) is a protein
from Homo sapiens identified by UniProt accession
P60413, 245 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | Keratin-associated protein 10-12 |
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| UniProt accession | P60413 |
|---|
| Gene | KRTAP10-12 |
|---|
| Organism | Homo sapiens |
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| Length | 245 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (8)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.18
- low grade glioma · score 0.11
- neurofibrillary tangles measurement · score 0.06
- balding measurement · score 0.03
- hair shape measurement · score 0.03
- deafness · score 0.01
- hearing loss, autosomal recessive · score 0.01
- small cell lung carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60413-F1 | alphafold | PREDICTED | 39.12 | — |
Amino-acid sequence (245 residues)
MSVCSSDLSY GSRVCLPGSC DSCSDSWQVD DCPESCCEPP CCAPAPCLSL VCTPVSRVSS PCCRVTCEPS PCQSGCTSSC TPSCCQQSSC QPACCTSSPC QQACCVPVCC KTVCCKPVCC MPVCCGPSSS CCQQSSCQPA CCISSPCQQS CCVPVCCKPI CCVPVCSGAS SLCCQQSSCQ PACCTTSCCR PSSSVSLLCR PVCRPARRVP VPSCCVPTSS CQPSCGRLAS CGSLLCRPTC SRLAC
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