About Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) is a protein
from Homo sapiens identified by UniProt accession
P60484, 403 residues long.
MolForge cross-references it against 0 known binders and
1,715 disease associations.
Target properties
| Protein name | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN |
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| UniProt accession | P60484 |
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| Gene | PTEN |
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| Organism | Homo sapiens |
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| Length | 403 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (1715)
Diseases linked to this target (Open Targets).
- Cowden syndrome 1 · score 0.87
- PTEN hamartoma tumor syndrome · score 0.82
- macrocephaly-autism syndrome · score 0.82
- Cowden disease · score 0.77
- melanoma · score 0.76
- glioma susceptibility 2 · score 0.74
- prostate adenocarcinoma · score 0.74
- Bannayan-Riley-Ruvalcaba syndrome · score 0.73
- head and neck squamous cell carcinoma · score 0.72
- endometrial cancer · score 0.70
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60484-F1 | alphafold | PREDICTED | 83.03 | — |
Amino-acid sequence (403 residues)
MTAIIKEIVS RNKRRYQEDG FDLDLTYIYP NIIAMGFPAE RLEGVYRNNI DDVVRFLDSK HKNHYKIYNL CAERHYDTAK FNCRVAQYPF EDHNPPQLEL IKPFCEDLDQ WLSEDDNHVA AIHCKAGKGR TGVMICAYLL HRGKFLKAQE ALDFYGEVRT RDKKGVTIPS QRRYVYYYSY LLKNHLDYRP VALLFHKMMF ETIPMFSGGT CNPQFVVCQL KVKIYSSNSG PTRREDKFMY FEFPQPLPVC GDIKVEFFHK QNKMLKKDKM FHFWVNTFFI PGPEETSEKV ENGSLCDQEI DSICSIERAD NDKEYLVLTL TKNDLDKANK DKANRYFSPN FKVKLYFTKT VEEPSNPEAS SSTSVTPDVS DNEPDHYRYS DTTDSDPENE PFDEDQHTQI TKV
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