Gamma-aminobutyric acid receptor-associated…

About Gamma-aminobutyric acid receptor-associated protein-like 2

Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) is a protein from Homo sapiens identified by UniProt accession P60520, 117 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Gamma-aminobutyric acid receptor-associated protein-like 2
UniProt accession	P60520
Gene	GABARAPL2
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

age at first sexual intercourse measurement · score 0.16
smoking status measurement · score 0.09
blood protein measurement · score 0.08
smoking initiation · score 0.07
smoking behavior · score 0.07
attention deficit hyperactivity disorder · score 0.06
substance abuse · score 0.06
antisocial behaviour measurement · score 0.06
Blackfan-Diamond anemia · score 0.06
hemoglobin D disease · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60520-F1	alphafold	PREDICTED	94.78	—

Amino-acid sequence (117 residues)

MKWMFKEDHS LEHRCVESAK IRAKYPDRVP VIVEKVSGSQ IVDIDKRKYL VPSDITVAQF MWIIRKRIQL PSEKAIFLFV DKTVPQSSLT MGQLYEKEKD EDGFLYVAYS GENTFGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2)