Profilin-3 (PFN3)

About Profilin-3

Profilin-3 (PFN3) is a protein from Homo sapiens identified by UniProt accession P60673, 137 residues long. MolForge cross-references it against 0 known binders and 123 disease associations.

Target properties

Protein name	Profilin-3
UniProt accession	P60673
Gene	PFN3
Organism	Homo sapiens
Length	137 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (123)

Diseases linked to this target (Open Targets).

azoospermia · score 0.11
spermatogenic failure 51 · score 0.10
spermatogenic failure, X-linked, 3 · score 0.10
spermatogenic failure 20 · score 0.10
spermatogenic failure 40 · score 0.10
spermatogenic failure 39 · score 0.10
spermatogenic failure 47 · score 0.10
spermatogenic failure 65 · score 0.10
spermatogenic failure 8 · score 0.10
spermatogenic failure 72 · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60673-F1	alphafold	PREDICTED	94.24	—

Amino-acid sequence (137 residues)

MGDWKVYISA VLRDQRIDDV AIVGHADNSC VWASRPGGLL AAISPQEVGV LTGPDRHTFL QAGLSVGGRR CCVIRDHLLA EGDGVLDART KGLDARAVCV GRAPRALLVL MGRRGVHGGI LNKTVHELIR GLRMQGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards