Complement C1q tumor necrosis factor-related…

About Complement C1q tumor necrosis factor-related protein 8

Complement C1q tumor necrosis factor-related protein 8 (C1QTNF8) is a protein from Homo sapiens identified by UniProt accession P60827, 252 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Complement C1q tumor necrosis factor-related protein 8
UniProt accession	P60827
Gene	C1QTNF8
Organism	Homo sapiens
Length	252 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

body height · score 0.21
glioblastoma multiforme · score 0.09
glioblastoma · score 0.02
IGF-1 measurement · score 0.02
multiple sclerosis · score 0.02
heel bone mineral density · score 0.02
insulin like growth factor measurement · score 0.02
brain cancer · score 0.01
pachyonychia congenita · score 0.01
neoplasm · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60827-F1	alphafold	PREDICTED	78.66	—

Amino-acid sequence (252 residues)

MAAPALLLLA LLLPVGAWPG LPRRPCVHCC RPAWPPGPYA RVSDRDLWRG DLWRGLPRVR PTIDIEILKG EKGEAGVRGR AGRSGKEGPP GARGLQGRRG QKGQVGPPGA ACRRAYAAFS VGRREGLHSS DHFQAVPFDT ELVNLDGAFD LAAGRFLCTV PGVYFLSLNV HTWNYKETYL HIMLNRRPAA VLYAQPSERS VMQAQSLMLL LAAGDAVWVR MFQRDRDNAI YGEHGDLYIT FSGHLVKPAA EL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Complement C1q tumor necrosis factor-related protein 8 (C1QTNF8)