About Zona pellucida sperm-binding protein 1
Zona pellucida sperm-binding protein 1 (ZP1) is a protein
from Homo sapiens identified by UniProt accession
P60852, 638 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Zona pellucida sperm-binding protein 1 |
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| UniProt accession | P60852 |
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| Gene | ZP1 |
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| Organism | Homo sapiens |
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| Length | 638 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- female infertility due to zona pellucida defect · score 0.64
- cutaneous melanoma · score 0.25
- lung adenocarcinoma · score 0.25
- genetic disorder · score 0.19
- squamous cell lung carcinoma · score 0.18
- breast adenocarcinoma · score 0.16
- glioblastoma multiforme · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- blood protein measurement · score 0.08
- primary ovarian insufficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60852-F1 | alphafold | PREDICTED | 72.96 | — |
Amino-acid sequence (638 residues)
MAGGSATTWG YPVALLLLVA TLGLGRWLQP DPGLPGLRHS YDCGIKGMQL LVFPRPGQTL RFKVVDEFGN RFDVNNCSIC YHWVTSRPQE PAVFSADYRG CHVLEKDGRF HLRVFMEAVL PNGRVDVAQD ATLICPKPDP SRTLDSQLAP PAMFSVSTPQ TLSFLPTSGH TSQGSGHAFP SPLDPGHSSV HPTPALPSPG PGPTLATLAQ PHWGTLEHWD VNKRDYIGTH LSQEQCQVAS GHLPCIVRRT SKEACQQAGC CYDNTREVPC YYGNTATVQC FRDGYFVLVV SQEMALTHRI TLANIHLAYA PTSCSPTQHT EAFVVFYFPL THCGTTMQVA GDQLIYENWL VSGIHIQKGP QGSITRDSTF QLHVRCVFNA SDFLPIQASI FPPPSPAPMT QPGPLRLELR IAKDETFSSY YGEDDYPIVR LLREPVHVEV RLLQRTDPNL VLLLHQCWGA PSANPFQQPQ WPILSDGCPF KGDSYRTQMV ALDGATPFQS HYQRFTVATF ALLDSGSQRA LRGLVYLFCS TSACHTSGLE TCSTACSTGT TRQRRSSGHR NDTARPQDIV SSPGPVGFED SYGQEPTLGP TDSNGNSSLR PLLWAVLLLP AVALVLGFGV FVGLSQTWAQ KLWESNRQ
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