Ribose-phosphate pyrophosphokinase 1 (PRPS1)

About Ribose-phosphate pyrophosphokinase 1

Ribose-phosphate pyrophosphokinase 1 (PRPS1) is a protein from Homo sapiens identified by UniProt accession P60891, 318 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.

Target properties

Protein name	Ribose-phosphate pyrophosphokinase 1
UniProt accession	P60891
Gene	PRPS1
Organism	Homo sapiens
Length	318 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (92)

Diseases linked to this target (Open Targets).

phosphoribosylpyrophosphate synthetase superactivity · score 0.79
Charcot-Marie-Tooth disease X-linked recessive 5 · score 0.77
Arts syndrome · score 0.76
X-linked hereditary sensory and autonomic neuropathy with deafness · score 0.67
X-linked Charcot-Marie-Tooth disease type 5 · score 0.62
X-linked nonsyndromic hearing loss · score 0.62
Lethal ataxia with deafness and optic atrophy · score 0.55
Charcot-Marie-Tooth disease · score 0.53
Retinal dystrophy · score 0.53
hearing loss · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60891-F1	alphafold	PREDICTED	94.81	—

Amino-acid sequence (318 residues)

MPNIKIFSGS SHQDLSQKIA DRLGLELGKV VTKKFSNQET CVEIGESVRG EDVYIVQSGC GEINDNLMEL LIMINACKIA SASRVTAVIP CFPYARQDKK DKSRAPISAK LVANMLSVAG ADHIITMDLH ASQIQGFFDI PVDNLYAEPA VLKWIRENIS EWRNCTIVSP DAGGAKRVTS IADRLNVDFA LIHKERKKAN EVDRMVLVGD VKDRVAILVD DMADTCGTIC HAADKLLSAG ATRVYAILTH GIFSGPAISR INNACFEAVV VTNTIPQEDK MKHCSKIQVI DISMILAEAI RRTHNGESVS YLFSHVPL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards