Probable G-protein coupled receptor 85 (GPR85)

About Probable G-protein coupled receptor 85

Probable G-protein coupled receptor 85 (GPR85) is a protein from Homo sapiens identified by UniProt accession P60893, 370 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Probable G-protein coupled receptor 85
UniProt accession	P60893
Gene	GPR85
Organism	Homo sapiens
Length	370 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.31
body mass index · score 0.28
eosinophil count · score 0.26
eosinophil percentage of leukocytes · score 0.23
body fat percentage · score 0.20
fat body mass · score 0.20
body weight · score 0.19
lean body mass · score 0.18
neutrophil percentage of granulocytes · score 0.18
eosinophil percentage of granulocytes · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60893-F1	alphafold	PREDICTED	82.62	—

Amino-acid sequence (370 residues)

MANYSHAADN ILQNLSPLTA FLKLTSLGFI IGVSVVGNLL ISILLVKDKT LHRAPYYFLL DLCCSDILRS AICFPFVFNS VKNGSTWTYG TLTCKVIAFL GVLSCFHTAF MLFCISVTRY LAIAHHRFYT KRLTFWTCLA VICMVWTLSV AMAFPPVLDV GTYSFIREED QCTFQHRSFR ANDSLGFMLL LALILLATQL VYLKLIFFVH DRRKMKPVQF VAAVSQNWTF HGPGASGQAA ANWLAGFGRG PTPPTLLGIR QNANTTGRRR LLVLDEFKME KRISRMFYIM TFLFLTLWGP YLVACYWRVF ARGPVVPGGF LTAAVWMSFA QAGINPFVCI FSNRELRRCF STTLLYCRKS RLPREPYCVI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards