26S proteasome complex subunit SEM1 (SEM1)

About 26S proteasome complex subunit SEM1

26S proteasome complex subunit SEM1 (SEM1) is a protein from Homo sapiens identified by UniProt accession P60896, 70 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.

Target properties

Protein name	26S proteasome complex subunit SEM1
UniProt accession	P60896
Gene	SEM1
Organism	Homo sapiens
Length	70 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (59)

Diseases linked to this target (Open Targets).

cancer · score 0.54
cortical surface area measurement · score 0.47
HIV infection · score 0.47
bone density · score 0.44
heel bone mineral density · score 0.44
brain measurement · score 0.43
alkaline phosphatase measurement · score 0.43
bone quantitative ultrasound measurement · score 0.43
neuroimaging measurement · score 0.43
reticulocyte count · score 0.38

3D Structure

Predicted structure for P60896 is available from the AlphaFold Protein Structure Database.

Amino-acid sequence (70 residues)

MSEKKQPVDL GLLEEDDEFE EFPAEDWAGL DEDEDAHVWE DNWDDDNVED DFSNQLRAEL EKHGYKMETS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards