About Proteasome subunit alpha type-6
Proteasome subunit alpha type-6 (PSMA6) is a protein
from Homo sapiens identified by UniProt accession
P60900, 246 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Proteasome subunit alpha type-6 |
|---|
| UniProt accession | P60900 |
|---|
| Gene | PSMA6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 246 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (140)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.46
- thyroid gland adenocarcinoma · score 0.30
- breast adenocarcinoma · score 0.30
- lung adenocarcinoma · score 0.29
- urinary bladder cancer · score 0.28
- glioblastoma multiforme · score 0.28
- head and neck squamous cell carcinoma · score 0.28
- clear cell renal carcinoma · score 0.27
- myocardial infarction · score 0.19
- creatine kinase measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P60900-F1 | alphafold | PREDICTED | 96.04 | — |
Amino-acid sequence (246 residues)
MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVI VTQKKVPDKL LDSSTVTHLF KITENIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYEIP VDMLCKRIAD ISQVYTQNAE MRPLGCCMIL IGIDEEQGPQ VYKCDPAGYY CGFKATAAGV KQTESTSFLE KKVKKKFDWT FEQTVETAIT CLSTVLSIDF KPSEIEVGVV TVENPKFRIL TEAEIDAHLV ALAERD
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