Cell division control protein 42 homolog (CDC42)

About Cell division control protein 42 homolog

Cell division control protein 42 homolog (CDC42) is a protein from Homo sapiens identified by UniProt accession P60953, 191 residues long. MolForge cross-references it against 0 known binders and 525 disease associations.

Target properties

Protein name	Cell division control protein 42 homolog
UniProt accession	P60953
Gene	CDC42
Organism	Homo sapiens
Length	191 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (525)

Diseases linked to this target (Open Targets).

macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome · score 0.75
hemophagocytic syndrome · score 0.46
genetic disorder · score 0.46
exanthem · score 0.46
Neurodevelopmental disorder · score 0.46
Neurodevelopmental abnormality · score 0.40
Postnatal growth retardation · score 0.40
Abnormality of blood and blood-forming tissues · score 0.40
Abnormality of the immune system · score 0.40
Abnormal facial shape · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60953-F1	alphafold	PREDICTED	93.48	—

Amino-acid sequence (191 residues)

MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCPKTPF LLVGTQIDLR DDPSTIEKLA KNKQKPITPE TAEKLARDLK AVKYVECSAL TQKGLKNVFD EAILAALEPP EPKKSRRCVL L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards