Glia maturation factor beta (GMFB)

About Glia maturation factor beta

Glia maturation factor beta (GMFB) is a protein from Homo sapiens identified by UniProt accession P60983, 142 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Glia maturation factor beta
UniProt accession	P60983
Gene	GMFB
Organism	Homo sapiens
Length	142 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
refractive error · score 0.08
neoplasm · score 0.08
hepatocellular carcinoma · score 0.08
calf circumference measurement · score 0.07
reticulocyte count · score 0.07
refractive error measurement · score 0.07
cortical surface area measurement · score 0.07
reticulocyte measurement · score 0.06
Myopia · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P60983-F1	alphafold	PREDICTED	94.16	—

Amino-acid sequence (142 residues)

MSESLVVCDV AEDLVEKLRK FRFRKETNNA AIIMKIDKDK RLVVLDEELE GISPDELKDE LPERQPRFIV YSYKYQHDDG RVSYPLCFIF SSPVGCKPEQ QMMYAGSKNK LVQTAELTKV FEIRNTEDLT EEWLREKLGF FH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards